This invention provides a compound comprising the structure: YDINYYTSE
wherein each T represents a threonine, each S represents a serine, each E represents
a glutamic acid, each Y represents a tyrosine; each D represents an aspartic acid,
each I represents an isoleucine; and each N represents an asparagine; wherein
represents from 0 to 9 amino acids, with the proviso that if there are more than
2 amino acids, they are joined by peptide bonds in consecutive order and have a
sequence identical to the sequence set forth in SEQ ID NO: 1 beginning with the
I at position 9 and extending therefrom in the amino terminal direction; wherein
represents from 0 to 13 amino acids, with the proviso that if there are
more than 2 amino acids, they are joined by peptide bonds in consecutive order
and have a sequence identical to the sequence set forth in SEQ ID NO: 1 beginning
with the P at position 19 and extending therefrom in the carboxy terminal direction;
wherein represents an amino group or an acetylated amino group; wherein
represents a carboxyl group or an amidated carboxyl group; wherein all
of ,Y,D,I,N,Y,Y,T,S,E and are joined together by peptide bonds;
further provided that at least two tyrosines in the compound are sulfated.
