The present invention is directed to aryl sulfamide derivatives of formula
I: ##STR00001## or a pharmaceutically acceptable salt, stereoisomer or
tautomer thereof, which are monoamine reuptake inhibitors, compositions
containing these derivatives, and methods of their use for the prevention
and treatment of conditions, including, inter alia, vasomotor symptoms,
sexual dysfunction, gastrointestinal disorders and genitourinary
disorder, depression disorders, endogenous behavioral disorders,
cognitive disorders, diabetic neuropathy, pain, and other diseases or
disorders.