A method to anticipate and prevent application non-conformance is disclosed. The method includes making available a configuration management database (CMDB) having configuration information of a plurality of system resources and dependency information of a plurality of applications related to the plurality of system resources. The method also includes making available a plurality of rules to establish a plurality of operating conditions that are statistically probable to cause a non-conformance of each system resource of the plurality of system resources, and combining each rule with the CMDB to determine the dependency of each application upon each operating condition. The method proceeds with performing a response action in response to determining that any of the operating conditions are such to cause a statistically probable non-conformance of any of the plurality of applications.