Use of calreticulin and calreticulin fragments to inhibit endothelial cell growth and angiogenesis, and suppress tumor growth

   
   

Methods for inhibiting endothelial cell growth and angiogenesis, and suppressing tumor growth using calreticulin, fragments of calreticulin and variants of calreticulin are provided. Such methods are useful for the treatment of cancer and diseases associated with unwanted angiogenesis, for example chronic retinal detachment.

Des méthodes pour empêcher la croissance et l'angiogenesis endothéliaux de cellules, et supprimer la croissance de tumeur en utilisant le calreticulin, les fragments du calreticulin et les variantes du calreticulin sont fournies. De telles méthodes sont utiles pour le traitement du cancer et des maladies liés à l'angiogenesis non désiré, par exemple détachement rétinien chronique.

 
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