Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade

   
   

The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

La invención se relaciona con el aryl policíclico substituido y el pyridone del heteroaryl compone útil mientras que los inhibidores de los proteases del serine de la coagulación conectan en cascada y los compuestos, las composiciones y los métodos para la terapia del anticoagulante para el tratamiento y la prevención de una variedad de condiciones thrombotic incluyendo arteria coronaria y enfermedades cerebrovasculares.

 
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> Secreted protein HEMAE80

> Methods for identifying and isolating tissue-specific lumen-exposed molecules

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