Use of tetrahydropteridine derivatives as no synthase inhibitors

   
   

The present invention relates to the use of pteridine derivatives of the formula I ##STR1## in which X is O or NH and R.sup.4, for example, is hydrogen, phenyl or the radical R.sup.4a --CH.sub.2 -- and R.sup.4a, for example, is hydrogen, (C.sub.1 -C.sub.4)-alkylmercapto, the radical --NR.sup.11 R.sup.12 or the radical --OR.sup.13, and in which R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, R.sup.7, R.sup.11, R.sup.12 and R.sup.13 have the meanings given in claim 1, which are nitric oxide synthase inhibitors, for the treatment of diseases which are caused by an increased nitric oxide level.

La presente invenzione riguarda l'uso dei derivati di pteridine del ## del ## STR1 di formula I in cui la X è O o il NH e R.sup.4, per esempio, è idrogeno, fenile o il R.sup.4a radicale -- CH.sub.2 -- e R.sup.4a, per esempio, è idrogeno, (C.sub.1 - C.sub.4)-alkylmercapto, il radicale -- NR.sup.11 R.sup.12 o il radicale -- OR.sup.13 ed in quale R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, R.sup.7, R.sup.11, R.sup.12 e R.sup.13 hanno i significati dati nella rivendicazione 1, che sono inibitori nitrici di synthase dell'ossido, per il trattamento delle malattie che sono causate da un livello nitrico aumentato dell'ossido.

 
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