Therapeutic and diagnostic domain 1 .beta.2GPI polypeptides and methods of using same

   
   

The present invention provides domain 1 .beta..sub.2 GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 .beta..sub.2 GPI polypeptides and mimetics. Domain 1 of .beta..sub.2 GPI has been shown to bind to anti-cardiolipin (.beta..sub.2 GPI-dependent antiphospholipid) antibodies, which are associated with several pathologies, such as thrombosis and fetal loss. The domain 1 .beta..sub.2 GPI polypeptides may be used to detect .beta..sub.2 GPI-dependent antiphospholipid antibodies in a sample. The invention further provides methods of inducing tolerance using these domain 1 .beta..sub.2 GPI polypeptides.

 
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