Multi-arm block copolymers as drug delivery vehicles

   
   

The invention provides multi-arm block copolymers useful as drug delivery vehicles comprising a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, methods of making such copolymers and pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.

A invenção fornece os copolymers do bloco do multi-braço úteis como os veículos da entrega da droga que compreendem uma molécula central do núcleo, tal como um resíduo de um polyol, e ao menos os três braços do copolymer unidos covalently à molécula central do núcleo, cada braço do copolymer que compreende um segmento hydrophobic interno do polímero unido covalently à molécula central do núcleo e um segmento hydrophilic exterior do polímero unido covalently ao segmento hydrophobic do polímero, wherein a molécula central do núcleo e o segmento hydrophobic do polímero definem uma região hydrophobic do núcleo. O solubility de agentes biològica ativos hydrophobic pode ser melhorado pela armadilha dentro da região hydrophobic do núcleo do copolymer do bloco. A invenção mais adicional inclui composições pharmaceutical including tais copolymers do bloco, métodos de fazer tais copolymers e composições pharmaceutical, e métodos de usar os copolymers do bloco como veículos da entrega da droga.

 
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