Inhibitors of farnesyl protein transferase

   
   

This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation. ##STR1##

Questa invenzione riguarda i residui della formula (i) che inibiscono il farnesylation dei prodotti del gene con inibizione della transferasi della farnesyl-proteina degli enzimi (FPTase). L'invenzione inoltre si riferisce ai metodi di produzione i residui, le composizioni farmaceutiche e dei metodi di trattare le malattie, particolarmente cancro, che sono mediate con il farnesylation. ## del ## STR1

 
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