The present invention relates to water-insoluble, crosslinked amide derivatives
of hyaluronic acid and manufacturing method thereof, where the amide derivatives
of hyaluronic acid are characterized by crosslinking, of polymer or oligomer having
two or more amine groups, with hyaluronic acid or its hyaluronate salts through
amidation reaction. The water-insoluble, crosslinked amide derivatives of hyaluronic
acid according to the present invention may be diversely used for prevention of
adhesion after surgical operation, correction of facial wrinkles, dermal augmentation,
tissue engineering, osteoarthritic viscosupplement etc.
