The present invention relates PI3K crystals, polypeptide muteins, polypeptide
fragments, antibodies thereto, nucleic acids coding for these polypeptides, methods
of modifying PI3K activity, and methods of modulating PI3K activity.
These include polypeptides and methods thereof, relating to, e.g., phospholipid
binding, lipid kinase activity, modulating Ras activity in activating the PI3K,
binding of PI3K to cell membranes, and modulating proteinprotein
interactions with PI3K.
