RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)

   
   

The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor (e.g., VEGFr1, VEGFr2 and/or VEGFr3) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against VEGF and/or VEGFr gene expression and/or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of cancer, proliferative diseases, and any other disease or condition that responds to modulation of VEGF and/or VEGFr expression or activity.

A invenção atual concerne os métodos e os reagents úteis em modular o fator endothelial vascular do crescimento (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) e/ou a expressão endothelial vascular do gene do receptor do fator do crescimento (por exemplo, VEGFr1, VEGFr2 e/ou VEGFr3) em uma variedade das aplicações, including o uso no validation therapeutic, diagnóstico, do alvo, e em aplicações genomic da descoberta. Especificamente, a invenção relaciona-se às moléculas pequenas do ácido nucleic, tais como o ácido nucleic interferindo do short (siNA), RNA interferindo curto (siRNA), RNA double-stranded (dsRNA), micro-micro-RNA (miRNA), e as moléculas curtas do RNA do hairpin (shRNA) capazes de mediar a interferência do RNA (RNAi) de encontro à expressão e/ou à atividade do gene de VEGF e/ou de VEGFr. As moléculas pequenas do ácido nucleic são úteis no diagnóstico e o tratamento do cancer, doenças proliferative, e toda a outra doença ou circunstância que responderem à modulação de VEGF e/ou expressão ou atividade de VEGFr.

 
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