Biosynthetic platform for cardioprotective stress response in human fetal heart tissue

   
   

The present invention is directed toward elucidation of a human fetal gene expression program in response to simulated ischemia/reperfusion (I/R) in order to identify molecular targets which account for the innate cardioprotection exhibited by the fetal phenotype.

 
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< RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)

< RNA interference mediated inhibition hairless (HR) gene expression using short interfering nucleic acid (siNA)

> Partial or full A1 agonists - N6 heterocyclic 5' thio substituted adenosine derivatives

> Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen

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