Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives

   
   

The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency, do not suppress blood coagulation, and have little hepatotoxic effect.

Присытствыющий вымысел относит к фармацевтическим комбинациям аналгетиков opioid и non-opioid в плотной примеси с аналгетиком от серии Н-n-acylated производных 4-hydroxyphenylamine, соединенной через мост алкилена к атому азота группы и методов 1,2-benzisothiazol-3(2H)-one 1,1-dioxide для их пользы разрешить боль в mammals. Противоболевым potency комбинаций увеличенный экспонатом противоболевой, не подавляет свертывание крови, и имеет меньшее гепатотоксическое влияние.

 
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