Compounds of the formula ##STR1## are provided wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl. The compounds are inhibitors of cyclooxygenase-2 activity, useful for treating inflammation and cyclooxygenase-mediated disorders.

Los compuestos del ## del ## STR1 del fórmula se proporcionan en donde R.sub.1, R.sub.2, R.sub.3 y R.sub.4 se seleccionan independientemente del hidrógeno que consiste en del grupo, halógeno, oxhidrilo, C.sub.1 - C.sub.8 alkyl, C.sub.1 - C.sub.6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, un acylsulfamyl más bajo y trifluoromethyl. Los compuestos son inhibidores de la actividad cyclooxygenase-2, útiles para tratar la inflamación y desórdenes cyclooxygenase-mediados.

 
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