Use of substituted N, N-disubstituted reverse aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity

The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted reverse aminoalcohols. A preferred specific N,N-disubstituted reserve aminoalcohol is the compound: ##STR1##
La invención se relaciona con el uso de los compuestos terciarios-heteroalkylamine policíclicos substituidos del aryl y del heteroaryl útiles mientras que los inhibidores del éster del cholesteryl transfieren la proteína (CETP; protei'na-Yo de la transferencia del lípido del plasma) y compuestos, composiciones y métodos para tratar atherosclerosis y otras enfermedades de la arteria coronaria. Los compuestos terciarios-heteroalkylamine preferidos son N substituida, aminoalcoholes reversos N-n-disubstituted. Una N específica preferida, aminoalcohol N-n-disubstituted de la reserva es el compuesto: ## del ## STR1

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< use of substituted N,N-disubstituted mercapto amino compounds for inhibiting cholesteryl ester transfer protein activity

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> Use of substituted N, N-bis-phenyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity

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