use of substituted N,N-disubstituted mercapto amino compounds for inhibiting cholesteryl ester transfer protein activity

The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkyamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted mercapto amines. A preferred specific N,N-disubstituted mercapto amine is the compound: ##STR1##
De uitvinding heeft op gebruik van gesubstitueerde polycyclic aryl en heteroaryl nuttige betrekking tertiair-heteroalkyaminesamenstellingen aangezien de inhibitors van cholesteryl ester proteïne (CETP; overdracht eiwit-i van het plasmalipide) en samenstellingen, samenstellingen en methodes overbrengen om atherosclerose en andere kransslagaderziekten te behandelen. De aangewezen tertiair-heteroalkylaminesamenstellingen zijn gesubstitueerd N, n-Disubstituted mercaptoaminen. Aangewezen specifiek N, n-Disubstituted mercaptoamine is de samenstelling: ## STR1 ##

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< Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications

> Use of substituted N, N-disubstituted reverse aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity

> Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications

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