The present invention relates to a transformed plant cell expressing .beta.-amyloid gene, which is known as a causal substance of senile dementia in human, a transformed plant and a preparation method of the same, more particularly, to a transformed plant cell expressing tandem repeats of .beta.-amyloid gene, a transformed plant produced by tissue-culturing the above cells and a preparation method of the same. The transformed plant of the present invention expresses multiple .beta.-amyloid protein, so that the plant can be effectively used for the preparation of an oral vaccine composition for the prevention of senile dementia in human.

 
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> Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664

> Arctic .beta. amyloid protofibril

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