An article of footwear having a rubber outsole, a polyurethane midsole bonded to the rubber outsole by polyurethane (PU) adhesive, and a polyurethane upper bonded to the midsole and the rubber outsole by injection molding. The invention also relates to a method of manufacturing an article of footwear comprising the steps of applying a layer of primer to a selected portion of a rubber outsole and allowing the layer of primer to dry; applying a first layer of PU adhesive over the primed portion of the outsole and allowing said first layer of PU adhesive to dry; applying a second layer of PU adhesive over the dried first layer of PU adhesive and allowing the second layer of PU adhesive to dry; forming, separately, a polyurethane upper by injection molding; setting the outsole and the upper in a mold; and, forming, via injection molding, a polyurethane midsole and activating the PU adhesive to bond the outsole to the midsole and to the upper, thereby forming the article of footwear.