A configurable chassis guidance system and method are described. The system may be practiced as a chassis and/or a module or an element thereof (e.g., a mating guide). The system and method allow reconfiguration of multiple modules of various module widths without the need for removal or reinstallation of module guides mounted on the chassis. As an example, a single-width module may be removed and replaced by a double-width module or quadruple-width module without removing module guides used to engage the single-width module. As another example, a double-width module or quadruple-width module may be removed and replaced by a single-width module without removing module guides used to engage the double-width module or quadruple-width module. The system and method may be practiced so as not to impair compatibility of modules with card edge module guides that engage an edge of a circuit board of a module.