The present invention is directed to compounds of formula (I), (Ia),(Ic)
and (Id), compositions, and uses thereof as an inhibitor of the p38
kinase, and ##STR00001## wherein, inter alia R.sub.1 is
C(Z)N(R.sub.10')(CR.sub.10R.sub.20).sub.vR.sub.b,
C(Z)O(CR.sub.10R.sub.20).sub.vR.sub.b,
N(R.sub.10')C(Z)(CR.sub.10R.sub.20).sub.vR.sub.b;
N(R.sub.10')C(Z)N(R.sub.10')(CR.sub.10R.sub.20).sub.vR.sub.b; or
N(R.sub.10')OC(Z)(CR.sub.10R.sub.20).sub.vR.sub.b; R.sub.3 is C.sub.1-10
alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-10 alkyl, aryl,
arylC.sub.1-10 alkyl, heteroarylC.sub.1-10 alkyl, or a
heterocyclylC.sub.1-10 alkyl moiety, and wherein each of these moieties
may be optionally substituted; X is R.sub.2, OR.sub.2',
S(O).sub.mR.sub.2', (CH.sub.2).sub.n'N(R.sub.10')S(O).sub.mR.sub.2',
(CH.sub.2).sub.n'N(R.sub.10')C(O)R.sub.2',
(CH.sub.2).sub.n'NR.sub.4R.sub.14, (CH.sub.2).sub.n'N(R.sub.2
')(R.sub.2''), or N(R.sub.10')--R.sub.h--NH--C(.dbd.N--CN)NRqRq'; and
R.sub.2 is hydrogen, C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7
cycloalkylalkyl, aryl, arylC.sub.1-10 alkyl, heteroaryl,
heteroarylC.sub.1-10 alkyl, heterocyclic, or a heterocyclylC.sub.1-10
alkyl moiety, and wherein each of these moieties, excluding hydrogen, may
be optionally substituted; or a pharmaceutically acceptable salt thereof.
