A method for the identification of novel compounds that interact and
stabilize the ligand binding domain of estrogen-related receptor gamma
(ERR.gamma.), a methodology for producing diffraction quality crystal
structures in the presence of antagonist and agonist ligands, including
Bisphenol A, and the identification of novel biologically-active
compounds that have an effect on the transcriptional-activating activity
of ERR.gamma. are disclosed.