Disclosed are compounds of the formula: ##STR00001## and compounds of the formula: ##STR00002## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, u and v are as defined herein. Also disclosed are methods of treating pain (e.g., inflammatory pain, chronic pain, and neuropathic pain), methods of treating diabetes, and methods of inhibiting the absorption of cholesterol using compounds of formula I or IIA.