The invention relates to a gem-difluoride glycoconjugated compound with formula (I): where R represents II or a benzyl, acetyl, benzoyl alkyl group, R.sup.1 and R.sup.2 may be identical or different and represent H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl, tertiobutyldiphenylsilyl protective group or an acetal group of the CR'R' type, where R' and R' may be identical or different and represent H or an alkyl, aryl, benzyl or thiophene group, R.sup.3 represents H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl or tertiobutyldiphenylsilyl protective group, R.sup.4 represents OR'', NGR'GR', N.sub.3, or a phthalimide, where R'' represents H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl or tertiobutyldiphenylsilyl protective group, GR' and GR' may be identical or different and represent II or an alkyl, benzyl, benzoyl, acetyl, alkyloxycarbonyl, allyloxycarbonyl or benzyloxycarbonyl group, R.sup.5 represents a free or protected hydroxyl group or a halogen, R.sup.6 represents H or an alkyl, acetyl, benzyl, PO.sub.3H or PO.sub.3Na group. It is applicable to the preparation of compounds that can be used particularly for the treatment of cancer. ##STR00001##