A herbal composition, containing natural COX-2, includes a powder of Labiatae plant, wherein the herbal composition is prepared by a method including the steps of dehydrating the Labiatae plant and grinding the dried Labiatae plant into a powdered form. The herbal composition is used for treatment of a disease including Nephritis, Lymphoma and colorectal cancer, Acute, chronic, and bile-reflux cholecystitis, and aphonia. The herbal composition is formed as an internal treatment having an administrative form selected from the group consisting of capsule, powder, solution, and syrup. The herbal composition is formed as an external treatment by mixing the powdered Labiatae plant with "Vaseline".