Disclosed is a pharmaceutical combination comprising a calcium receptor modulator and a bone resorption inhibitor, wherein the calcium receptor modulator comprises a compound represented by the formula (I): ##STR00001## wherein the ring A represents a 5- to 7-membered ring which may be substituted; the ring B represents a 5- to 7-membered heterocyclic ring which may be substituted; X.sup.1 represents CR.sup.1 (wherein R.sup.1 represents a hydrogen, a hydrocarbon group which may be substituted, or the like) or the like; X.sup.2 represents N or the like; Y represents C or the like; Ar represents a cyclic group which may be substituted; R represents a hydrocarbon group which may be substituted, or the like; and represents a single bond or a double bond; or a salt thereof or a prodrug of the compound or the salt.