The invention provides seed and plants of the spinach line designated OMB66-1101M. The invention thus relates to the plants, seeds and tissue cultures of spinach line OMB66-1101M, and to methods for producing a spinach plant produced by crossing a plant of spinach line OMB66-1101M with itself or with another spinach plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of spinach line OMB66-1101M, including the fruit and gametes of such plants.