A system for eradicating or neutralizing undesirable elements such as organisms or insects on or in a particular article to prevent harm to humans or animals coming in contact with or exposed to the article, comprising exposing predetermined surfaces of the article to a predetermined ultraviolet radiation to kill or neutralize undesirable elements on the surfaces of the article; and thereafter applying to the surfaces of the article an eradication technology treatment to further kill, neutralize and/or drive out and expose undesirable elements. After the application of the eradication technology treatment, the article surfaces may be exposed to a second ultraviolet radiation to kill or neutralize any remaining exposed undesirable elements. The apparatus may be in the form of a handheld device, mobile modular units, or a large unit on a trailer or in a fixed location.