The present invention relates to a compound represented by the formula (I): ##STR00001## (wherein, R.sup.3, R.sup.6, R.sup.7 and R.sup.21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.