An exemplary method of detecting a structure in a three-dimensional (3D) computed tomography ("CT") knee image is provided. An intensity prior mask is created based on a two-dimensional (2D) slice of the CT image. A seed point in the 2D slice is received or estimated. The seed point is in a Hoffa's pad region. A geometric prior mask is created based on the seed point. The intensity prior mask and the geometric mask are combined to form a region mask. A level-set contour is segmented from the 2D slice. The step of segmenting is constrained by the region mask.

 
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