Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such antagonism in animals are described herein. ##STR00001## where R, R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, R.sup.4, V, R.sup.6, R.sup.7, R.sup.8, R.sup.9, W and X are described herein.