Provided herein are compounds of the formula (I): ##STR00001## wherein R.sup.1-R.sup.8 are as described herein, R.sup.4 being aryl or heteroaryl Such compounds are particularly useful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine or dopamine.

 
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> Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods

> Bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, processes for their preparation, pharmaceutical compositions and methods for their use
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