In vitro cell-based methods for identifying compounds that inhibit Notch cleavage and methods for identifying .gamma.-secretase inhibitors that exhibit reduced induction of goblet cell metaplasia are provided. Also provided are methods of identifying compounds that inhibit cleavage of .gamma.-secretase substrates other than Notch and homogeneous compositions or cultures of Notch-expressing cells that undergo mucin-2 or mucin-5AC induction in response to a compound known to inhibit Notch cleavage and methods of their generation.

 
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> Tunable vehicle structural members and methods for selectively changing the mechanical properties thereto

> Multithreaded processor including a functional unit shared between multiple requestors and arbitration therefor

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