The present invention relates to methods of detecting the presence of
detergent- or urea-insoluble amyloid-like fibrils or protein aggregates
on filters. Preferably, said fibrils or aggregates are indicative of a
disease, preferably of a neurodegenerative disease such as Alzheimer's
disease or Huntington's disease. In addition, the present invention
relates to inhibitors identified by the method of the invention, to
pharmaceutical compositions comprising said inhibitors and to diagnostic
compositions useful for the investigation of said amyloid-like fibrils or
aggregates.