The present invention relates to a semiconductor device having first and second active device regions that are located in a semiconductor substrate and are isolated from each other by an isolation region therebetween, while the semiconductor device contains a first sub-lithographic interconnect structure having a width ranging from about 20 nm to about 40 nm for connecting the first active device region with the second active device region. The semiconductor device preferably contains at least one static random access memory (SRAM) cell located in the semiconductor substrate, and the first sub-lithographic interconnect structure directly cross-connects a pull-down transistor of the SRAM cell with a pull-up transistor thereof without any metal contact therebetween. The first sub-lithographic interconnect structure can be readily formed by lithographic patterning of a mask layer, followed by formation of sub-lithographic features using either self-assembling block copolymers or dielectric sidewall spacers.