A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R.sup.1 is H, C.sub.1-6alkyl, --C(A)D, C.sub.3-8cycloalkyl, aryl, het, aryl-C.sub.1-4alkyl or het-C.sub.1-4alkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted; A is S or O; D is H, C.sub.1-6alkyl, aryl, het, aryl-C.sub.1-4alkyl or het-C.sub.1-4alkyl; aryl represents phenyl, naphthyl, anthracyl or phenanthryl; het represents an aromatic or non-aromatic 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6-membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom; R.sup.2 is aryl.sup.1 or het.sup.1, each optionally substituted; n is 1 or 2, provided that when n is 1, m is 0 or 1 and when n is 2, m is 0, wherein if m is 0, then * represents a chiral centre; R.sup.3 is (CH.sub.2).sub.aE, wherein a is 0, 1 or 2 and E is a group selected from: Formula (i) wherein: X is O, S, NR.sup.12, (CH.sub.2).sub.v or a bond; b is 1, 2, 3 or 4; c is 1, 2 or 3; v is 1 or 2; R.sup.10 and .sup.11 are each independently H or C.sub.1-4 alkyl; and R.sup.12 is H, .sub.1-6 alkyl, C(O)C.sub.1-6 alkyl, SO.sub.2--C.sub.1-6alkyl; and wherein one or more pairs of hydrogen atoms on adjacent carbon or nitrogen atoms may be replaced by a corresponding number of double bonds, provided the ring system is not aromatic; Formula (ii) a carbocyclic spiro group containing 6 to 12 carbon atoms; Formula (iii) wherein: d is 1, 2, 3 or 4; a is 1, 2 or 3; f is 1 or 2; and R.sup.30 is H or C.sub.1-4alkyl; and wherein one or more pairs of hydrogen atoms on adjacent carbon atoms may be replaced by a corresponding number of double bonds, provided the ring system is not aromatic; Formula (iv) wherein: g is 0, 1, 2 or 3; J is NR.sup.40; and R.sup.40 is C(O)C.sub.1-6 alkyl, S0.sub.2-C.sub.1-6alkyl; Formula (v) wherein: h is 0, 1, 2 or 3; and R.sup.50 is H, C.sub.1-8alkyl, C.sub.1-8alkoxy, OH, halo, CF.sub.3, OCF.sub.3, SCF.sub.3, hydroxy-C.sub.1-6alkyl, C.sub.1-4alkoxy-C.sub.1-6alkyl and C.sub.1-4alkyl-S--C.sub.1-4alkyl; Formula (vi) --CH(cyclopropane).sub.2; Formula (vii) C.sub.1-6alkyl, substituted by at least one substituent; and Formula (viii) C.sub.3-8cycloalkyl-C.sub.1-6alkyl; wherein the C.sub.1-6alkyl moiety is substituted at any point other than at the junction with the C.sub.3-8cycloalkyl moiety, by at least one substituent. The compounds exhibit activity as both serotonin and/or noradrenaline re-uptake inhibitors and therefore have utility in a variety of therapeutic areas, for example urinary incontinence. ##STR00001##