Inhibitors of the phosphatase activity of soluble epoxide hydrolase (sEH)
are provided and are useful for in the treatment of diseases. These
Inhibitors are based on derivatives of various epoxide hydrolase
substrates that mimic the enzyme substrate so that there Is stable
Interaction with the enzyme catalytic site. These inhibitors are
potentially useful for the treatment of hypertension, vascular
inflammation, renal inflammation, and lung disease.