Spirocyclic heterocyclic derivatives, pharmaceutical compositions
containing these compounds, and methods for their pharmaceutical use are
disclosed. In certain embodiments, the spirocyclic heterocyclic
derivatives are ligands of the .delta.-opioid receptor and may be useful,
inter alia, for treating and/or preventing pain, anxiety,
gastrointestinal disorders, and other .delta.-opioid receptor-mediated
diseases, disorders, and/or conditions.