An embodiment of the present invention is directed to an instrumentation amplifier. The amplifier includes a first amplification sub-circuit, which includes an input stage for sensing a differential input and generating an intermediate current based thereon, a feedback stage, and an auto-zeroing circuit. The feedback stage is operable to generate a feedback current based on an output voltage of the amplifier. The auto-zeroing circuit is operable to generate a nulling current, which compensates for errors in the intermediate and feedback currents resulting from input offsets in the input and feedback stages. The amplifier further includes a second amplification sub-circuit, an output stage, and a switching circuit. The switching circuit switches the amplifier between first and second configurations. In the first configuration, the first amplification sub-circuit provides a first amplification path for the amplifier. In the second configuration, the second amplification sub-circuit provides a second amplification path for the amplifier.