The present invention is based on the discovery of a composition that
provides targeted anti-microbial effect. Specifically the composition
contains a targeting moiety which recognizes a target microbial organism
and an anti-microbial peptide moiety which has anti-microbial activity.
In addition, the present invention provides methods of treating a
microbial infection, e.g., on mucosal surfaces by using the compositions
provided by the present invention.