The present invention provides methods for screening for a molecule that antagonizes or agonizes RANK activity. One aspect of the invention involves the growth of RANK responsive cells in semi-solid medium, wherein exposure to a RANK antagonist promotes colony formation. Other aspects of the invention rely on promoter/reporter constructs using RANK responsive promoters derived from the MMP-9 and TRAP genes. Additional aspects of the invention exploit the ability of RANK to activate c-src activity, F-actin ring formation and CaPO.sub.4 resorption.

 
Web www.patentalert.com

< Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids

> Waveguide structure

> Herbicide combination

~ 00536