CRF peptide analogs that bind to CRFR1 with an affinity far greater than they bind to CRFR2. Some of these analogs exhibit CRF agonist activity. One exemplary analog that may be made by solid-phase synthesis is: (cyclo 31-34)[Ac-Pro.sup.4, D-Phe.sup.12, Nle.sup.18,21, Glu.sup.31, Lys.sup.34]-sucker urotensin(4-41).