The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. ##STR00001## Wherein R.sup.1 is a C.sub.6-C.sub.14 aromatic cyclic hydrocarbon group etc.; R.sup.2, R.sup.4 and R.sup.5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C.sub.1-C.sub.6 alkylene group etc.; X is a single bond, or a group represented by --CO--NH-- or --NH--CO--, etc.; and Y is a C.sub.3-C.sub.8 cycloalkyl group, a C.sub.6-C.sub.14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

 
Web www.patentalert.com

< Azole derivatives and pharmaceutical compositions containing them

> Method for transformation of conventional and commercially important polymers into durable and rechargeable antimicrobial polymeric materials

> Polypeptide for a TRP channel family member, TRP-PLIK2, and splice variants

~ 00522