A picture puzzle includes a background having at least one background object and at least one puzzle object disposed on such background. The picture puzzle is adapted with a predetermined matching alignment between a predetermined feature of the at least one puzzle object and a predetermined feature of the at least one background object. A method of using at least one picture puzzle for at least one of entertaining and soothing a patient awake during medical or dental procedure and promoting personal hygiene and a system for entertaining and soothing a patient awake during medical or dental procedure are also provided.