The invention provides compositions for intracellular delivery of biotinylated cargo. The compositions comprise a complex formed between (a) a fusion protein comprising a protein transduction domain linked to streptavidin and (b) a biotinylated cargo for intracellular delivery. In some embodiments, the protein transduction domain comprises the protein transduction domain of the Human Immunodeficiency Virus type 1 (HIV-1) TAT protein. The complex may further comprise a biotinylated endosomal releasing polymer, such as a poly(propylacrylic acid) polymer. The invention also provides methods for obtaining intracellular delivery of biotinylated cargo and methods for obtaining cytoplasmic delivery of biotinylated cargo.

 
Web www.patentalert.com

< Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same

> Glycopeptides derived from pancreatic structures, antibodies and applications thereof in diagnostics and therapeutics

> Stoichiometric conjugates of biocompatible polymers at the unpaired cysteine residue of the wild-type G-CSF

~ 00519