RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.

 
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< Presbyopia correction using patient data

> Therapeutic contact lens for pseudo-aphakic eyes and/or eyes with retinal neuro-degeneration

> Siloxane prepolymer containing pendant and end-capping cationic and polymerizable groups

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