A method for segmentation of an organ of a living subject with a variable shape and boundary and surrounded by structures and tissues in connection with an image containing the organ. In one embodiment, the method includes the steps of initializing a contour inside the organ in the image, introducing a speed function that is capable of accumulating spatial and temporal information of a propagating front of the contour, and evolving the contour toward the boundary of the organ using the introduced speed function so as to segment the organ.