An interactive learning appliance includes a body, a plurality of puzzle pieces and a control circuit. The body defines a receptacle. The puzzle pieces are provided to be placed in the receptacle selectively. Each puzzle piece has a distinct sensing surface with at least one hole defined therein. The control circuit installed in the body includes a storage circuit, an output circuit and an identification circuit. The storage circuit stores a plurality of content files each corresponding to a combination of the selected puzzle pieces. Each content file illustrates a meaning of the combination of the selected puzzle pieces. The identification circuit is configured to recognize each of the selected puzzle pieces via the hole of the sensing surface, to find out the corresponding content file according to an identification result of the selected puzzle pieces, and to have the output circuit execute the corresponding content file.