An assembly for securing the eyepiece of an endoscope to a digital camera includes a bar that supports the camera and a block that supports the eyepiece. The camera can be secured to the bar using the camera's tripod mounting hole. The block can normally move in three orthogonal linear directions relative to the bar, but can also be locked in a selected position relative to the bar. In this manner, the assembly can be adjusted so that the eyepiece of the endoscope contacts or nearly contacts the end of the barrel of the digital camera secured to the camera bar. Then, the support block can be locked into position to clamp the endoscope to the digital camera. A sheet is attached to one of the components and can be draped over the camera prior to use of the camera in a sterile environment.