In a method for producing a radionuclide, a target chamber is filled with target fluid and pressurized. A particle beam is applied to the target chamber to irradiate target material of the target fluid, and the target fluid becomes heated. The heated target liquid may expand out from the target chamber through a lower opening. A space including target fluid vapor may be created in an upper region of the target chamber. The upper region is sealed to maintain the vapor space.

 
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